4G2H

Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor

4G2H の概要

• エントリーDOI: 10.2210/pdb4g2h/pdb
• 関連するPDBエントリー: 4G1D 4G1Y 4G1Z 4G20 4G21 4G2I
• 分子名称: Vitamin D3 receptor A, Nuclear receptor coactivator 1, (3E,5E)-6-(3-{2-[3,4-bis(hydroxymethyl)phenyl]ethyl}phenyl)-1,1,1-trifluoro-2-(trifluoromethyl)octa-3,5-dien-2-ol, ... (4 entities in total)
• 機能のキーワード: vdr, transcription regulation, nuclear receptor, alpha helical sandwich, trasncription regulation, ligand, dna, phosphorylation, nucleus, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Danio rerio (leopard danio,zebra danio,zebra fish); 詳細
• 細胞内の位置: Nucleus: Q9PTN2; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36181.08

構造登録者

Ciesielski, F.,Sato, Y.,Moras, D.,Rochel, N. (登録日: 2012-07-12, 公開日: 2012-09-26, 最終更新日: 2024-02-28)

• 主引用文献: Ciesielski, F.,Sato, Y.,Chebaro, Y.,Moras, D.,Dejaegere, A.,Rochel, N.; Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor.; J.Med.Chem., 55:8440-8449, 2012; PubMed: 22957834; DOI: 10.1021/jm300858s

実験手法

X-RAY DIFFRACTION (2.5 Å)