4G20

Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor

Summary for 4G20

• Entry DOI: 10.2210/pdb4g20/pdb
• Related: 4G1D 4G1Y 4G1Z
• Descriptor: Vitamin D3 receptor A, Nuclear receptor coactivator 1, 3-(5'-{2-[3,4-bis(hydroxymethyl)phenyl]ethyl}-2'-methyl-2-propylbiphenyl-4-yl)pentan-3-ol, ... (4 entities in total)
• Functional Keywords: vdr, transcription regulation, nuclear receptor, alpha helical sandwich, ligand, dna, phosphorylation, nucleus, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Danio rerio (leopard danio,zebra danio,zebra fish); More
• Cellular location: Nucleus: Q9PTN2; Nucleus (By similarity): Q15788
• Total number of polymer chains: 2
• Total formula weight: 36153.26

Authors

Ciesielski, F.,Sato, Y.,Moras, D.,Rochel, N. (deposition date: 2012-07-11, release date: 2012-09-26, Last modification date: 2024-02-28)

• Primary citation: Ciesielski, F.,Sato, Y.,Chebaro, Y.,Moras, D.,Dejaegere, A.,Rochel, N.; Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor.; J.Med.Chem., 55:8440-8449, 2012; PubMed: 22957834; DOI: 10.1021/jm300858s

Experimental method

X-RAY DIFFRACTION (2.9 Å)