4G1F
Crystal Structure of human Dipeptidyl Peptidase IV in complex with a pyridopyrimidinedione analogue
Summary for 4G1F
Entry DOI | 10.2210/pdb4g1f/pdb |
Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-amino-6-(aminomethyl)-5-(2-bromophenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, ... (5 entities in total) |
Functional Keywords | protease, 8-bladed beta-propeller domain, aminopeptidase, cell membrane, glycoprotein, hydrolase, secreted, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 349441.22 |
Authors | Skene, R.J.,Gwaltney, S.L. (deposition date: 2012-07-10, release date: 2013-02-27, Last modification date: 2023-09-13) |
Primary citation | Lam, B.,Zhang, Z.,Stafford, J.A.,Skene, R.J.,Shi, L.,Gwaltney, S.L. Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors. Bioorg.Med.Chem.Lett., 22:6628-6631, 2012 Cited by PubMed: 23025999DOI: 10.1016/j.bmcl.2012.08.110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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