4G1C
Human SIRT5 bound to Succ-IDH2 and Carba-NAD
Summary for 4G1C
Entry DOI | 10.2210/pdb4g1c/pdb |
Related | 4FVT |
Descriptor | NAD-dependent protein deacylase sirtuin-5, mitochondrial, Succinylated IDH2 peptide, ZINC ION, ... (5 entities in total) |
Functional Keywords | sirtuin, succinylated peptide, carbanad, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Mitochondrion matrix. Isoform 1: Cytoplasm. Isoform 2: Mitochondrion: Q9NXA8 |
Total number of polymer chains | 4 |
Total formula weight | 60130.99 |
Authors | |
Primary citation | Szczepankiewicz, B.G.,Dai, H.,Koppetsch, K.J.,Qian, D.,Jiang, F.,Mao, C.,Perni, R.B. Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5. J.Org.Chem., 77:7319-7329, 2012 Cited by PubMed: 22849721DOI: 10.1021/jo301067e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.944 Å) |
Structure validation
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