Human topoisomerase iibeta in complex with DNA and mitoxantrone

Summary for 4G0V

Related3QX3 4G0U 4G0W 4J3N
DescriptorDNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... (6 entities in total)
Functional Keywordstoprim domain, winged-helix domain, coiled-coil domain, dna-binding and cleavage, nucleus, isomerase-dna-isomerase inhibitor complex, isomerase/dna/isomerase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q02880
Total number of polymer chains6
Total molecular weight197073.52
Wu, C.C.,Li, T.K.,Li, Y.C.,Chan, N.L. (deposition date: 2012-07-10, release date: 2013-07-17, Last modification date: 2014-03-12)
Primary citation
Wu, C.C.,Li, Y.C.,Wang, Y.R.,Li, T.K.,Chan, N.L.
On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41:10630-10640, 2013
PubMed: 24038465 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkt828
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20740.2%0.7%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution