4FZ7

Crystal structure of spleen tyrosine kinase complexed with 6-((1R,2S)-2-Amino-cyclohexylamino)-4-(6-ethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

4FZ7 の概要

• エントリーDOI: 10.2210/pdb4fz7/pdb
• 関連するPDBエントリー: 3FQE
• 分子名称: Tyrosine-protein kinase SYK, 6-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(6-ethylpyridin-2-yl)amino]pyridazine-3-carboxamide (3 entities in total)
• 機能のキーワード: kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34239.44

構造登録者

Kuglstatter, A.,Slade, M. (登録日: 2012-07-06, 公開日: 2013-07-10, 最終更新日: 2023-09-13)

• 主引用文献: Lucas, M.C.,Bhagirath, N.,Chiao, E.,Goldstein, D.M.,Hermann, J.C.,Hsu, P.Y.,Kirchner, S.,Kennedy-Smith, J.J.,Kuglstatter, A.,Lukacs, C.,Menke, J.,Niu, L.,Padilla, F.,Peng, Y.,Polonchuk, L.,Railkar, A.,Slade, M.,Soth, M.,Xu, D.,Yadava, P.,Yee, C.,Zhou, M.,Liao, C.; Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors.; J. Med. Chem., 57:2683-2691, 2014; PubMed: 24520947; DOI: 10.1021/jm401982j

実験手法

X-RAY DIFFRACTION (1.75 Å)