4FXL

Crystal structure of the D76N Beta-2 Microglobulin mutant

Summary for 4FXL

Entry DOI	10.2210/pdb4fxl/pdb
Descriptor	Beta-2-microglobulin, SODIUM ION, ACETATE ION, ... (5 entities in total)
Functional Keywords	immunoglobin, beta-sandwitch, amyloidosis, pathologic mutation, genetic disease, mhc class i, immune system
Biological source	Homo sapiens (human)
Cellular location	Secreted: P61769
Total number of polymer chains	1
Total formula weight	12066.53
Authors	Ricagno, S.,Bellotti, V.,Pepys, M.B.,Stoppini, M.,Bolognesi, M. (deposition date: 2012-07-03, release date: 2012-08-15, Last modification date: 2023-09-13)
Primary citation	Valleix, S.,Gillmore, J.D.,Bridoux, F.,Mangione, P.P.,Dogan, A.,Nedelec, B.,Boimard, M.,Touchard, G.,Goujon, J.M.,Lacombe, C.,Lozeron, P.,Adams, D.,Lacroix, C.,Maisonobe, T.,Plante-Bordeneuve, V.,Vrana, J.A.,Theis, J.D.,Giorgetti, S.,Porcari, R.,Ricagno, S.,Bolognesi, M.,Stoppini, M.,Delpech, M.,Pepys, M.B.,Hawkins, P.N.,Bellotti, V. Hereditary systemic amyloidosis due to Asp76Asn variant beta-2-microglobulin. N.Engl.J.Med., 366:2276-2283, 2012 Cited by PubMed: 22693999 DOI: 10.1056/NEJMoa1201356 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation