4FX8

Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

4FX8 の概要

• エントリーDOI: 10.2210/pdb4fx8/pdb
• 関連するPDBエントリー: 3LTP 4FX6 4FX8 4FXR
• 分子名称: Orotidine 5'-phosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: tim barrel, inhibitor bmp, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Methanothermobacter thermautotrophicus str. Delta H
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50355.55

構造登録者

Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. (登録日: 2012-07-02, 公開日: 2013-06-19, 最終更新日: 2023-09-13)

• 主引用文献: Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A.; Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme.; Biochemistry, 51:8665-8678, 2012; PubMed: 23030629; DOI: 10.1021/bi301188k

実験手法

X-RAY DIFFRACTION (1.9411 Å)