4FW0

Structure of rat nNOS heme domain in complex with N(delta)-methyl- N(omega)-hydroxy-L-arginine

4FW0 の概要

• エントリーDOI: 10.2210/pdb4fw0/pdb
• 関連するPDBエントリー: 4FVW 4FVX 4FVY 4FVZ
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, nitric oxide synthase, substrate analog
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99932.47

構造登録者

Li, H.,Poulos, T.L. (登録日: 2012-06-29, 公開日: 2013-05-15, 最終更新日: 2023-09-13)

• 主引用文献: Jansen Labby, K.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.; Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction; Biochemistry, 52:3062-3073, 2013; PubMed: 23586781; DOI: 10.1021/bi301571v

実験手法

X-RAY DIFFRACTION (1.95 Å)