4FRU

Crystal structure of horse wild-type cyclophilin B

4FRU の概要

• エントリーDOI: 10.2210/pdb4fru/pdb
• 分子名称: Peptidyl-prolyl cis-trans isomerase, ZINC ION, 1-ETHOXY-2-(2-METHOXYETHOXY)ETHANE, ... (5 entities in total)
• 機能のキーワード: cyclophilin-type ppiase, peptidyl-prolyl cis-trans isomerase; chaperone; foldase, p3h1-crtap-cypb complex; lh1 binding, endoplasmic reticulum, isomerase
• 由来する生物種: Equus caballus (domestic horse,equine)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20850.66

構造登録者

Boudko, S.P.,Ishikawa, Y.,Bachinger, H.P. (登録日: 2012-06-26, 公開日: 2012-11-14, 最終更新日: 2023-09-13)

主引用文献

Boudko, S.P.,Ishikawa, Y.,Lerch, T.F.,Nix, J.,Chapman, M.S.,Bachinger, H.P.
Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse.
BMC Res Notes, 5:626-626, 2012

PubMed Abstract: Hyperelastosis cutis is an inherited autosomal recessive connective tissue disorder. Affected horses are characterized by hyperextensible skin, scarring, and severe lesions along the back. The disorder is caused by a mutation in cyclophilin B.

PubMed: 23137129
DOI: 10.1186/1756-0500-5-626

実験手法

X-RAY DIFFRACTION (1.1 Å)