4FOX

Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed

4FOX の概要

• エントリーDOI: 10.2210/pdb4fox/pdb
• 関連するPDBエントリー: 3QJ7 4FOA 4FOG 4FOX 4FQS
• 分子名称: Thymidylate synthase, TOMUDEX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: structural genomics, tb structural genomics consortium, tbsgc, transferase, thymidylate synthase
• 由来する生物種: Mycobacterium tuberculosis
• 細胞内の位置: Cytoplasm (By similarity): P67044
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 245212.00

構造登録者

Reddy, M.C.M.,Bruning, J.B.,Sacchettini, J.C.,Harshbarger, W.,TB Structural Genomics Consortium (TBSGC) (登録日: 2012-06-21, 公開日: 2013-08-07, 最終更新日: 2023-09-13)

• 主引用文献: Reddy, M.C.M.,Bruning, J.B.,Sacchettini, J.C.,Harshbarger, W.; Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition; To be Published,

実験手法

X-RAY DIFFRACTION (2.3 Å)