4FOA

Crystal Structure of the Mtb ThyA in Complex with 5-fluoro-dUMP

4FOA の概要

• エントリーDOI: 10.2210/pdb4foa/pdb
• 関連するPDBエントリー: 3QJ7 4FOG 4FOX
• 分子名称: Thymidylate synthase, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE (3 entities in total)
• 機能のキーワード: structural genomics, tb structural genomics consortium, tbsgc, transferase, thymidylate synthase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 121192.32

構造登録者

Reddy, M.C.M.,Bruning, J.B.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (登録日: 2012-06-20, 公開日: 2013-08-07, 最終更新日: 2023-09-13)

• 主引用文献: Reddy, M.C.M.,Bruning, J.B.,Sacchettini, J.C.; Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition; To be Published,

実験手法

X-RAY DIFFRACTION (2.253 Å)