4FNY

Crystal structure of the R1275Q anaplastic lymphoma kinase catalytic domain in complex with a benzoxazole inhibitor

4FNY の概要

• エントリーDOI: 10.2210/pdb4fny/pdb
• 関連するPDBエントリー: 4FNW 4FNX 4FNZ 4FOB 4FOC 4FOD
• 分子名称: ALK tyrosine kinase receptor, N-(4-chlorophenyl)-5-[(6,7-dimethoxyquinolin-4-yl)oxy]-1,3-benzoxazol-2-amine (3 entities in total)
• 機能のキーワード: receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, cd246, phosphotransferase, npm-alk, eml4-alk, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: Q9UM73
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37252.01

構造登録者

Whittington, D.A.,Epstein, L.F.,Chen, H. (登録日: 2012-06-20, 公開日: 2012-08-29, 最終更新日: 2024-02-28)

• 主引用文献: Epstein, L.F.,Chen, H.,Emkey, R.,Whittington, D.A.; The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase.; J.Biol.Chem., 287:37447-37457, 2012; PubMed: 22932897; DOI: 10.1074/jbc.M112.391425

実験手法

X-RAY DIFFRACTION (2.45 Å)