4FMU

Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF

Summary for 4FMU

Entry DOI	10.2210/pdb4fmu/pdb
Descriptor	Histone-lysine N-methyltransferase SETD2, ZINC ION, (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-(propylamino)hexanoic acid, ... (5 entities in total)
Functional Keywords	structural genomics consortium, sgc, methyltransferase, set domain-containing protein 2, pr-snf, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Probable): Q9BYW2
Total number of polymer chains	1
Total formula weight	32575.18
Authors	Dong, A.,Zeng, H.,Ibanez, G.,Zheng, W.,Tempel, W.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Min, J.,Luo, M.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2012-06-18, release date: 2012-09-05, Last modification date: 2023-09-13)
Primary citation	Zheng, W.,Ibanez, G.,Wu, H.,Blum, G.,Zeng, H.,Dong, A.,Li, F.,Hajian, T.,Allali-Hassani, A.,Amaya, M.F.,Siarheyeva, A.,Yu, W.,Brown, P.J.,Schapira, M.,Vedadi, M.,Min, J.,Luo, M. Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2. J.Am.Chem.Soc., 134:18004-18014, 2012 Cited by PubMed: 23043551 DOI: 10.1021/ja307060p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation