4FMU

Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF

4FMU の概要

• エントリーDOI: 10.2210/pdb4fmu/pdb
• 分子名称: Histone-lysine N-methyltransferase SETD2, ZINC ION, (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-(propylamino)hexanoic acid, ... (5 entities in total)
• 機能のキーワード: structural genomics consortium, sgc, methyltransferase, set domain-containing protein 2, pr-snf, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (Probable): Q9BYW2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32575.18

構造登録者

Dong, A.,Zeng, H.,Ibanez, G.,Zheng, W.,Tempel, W.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Min, J.,Luo, M.,Wu, H.,Structural Genomics Consortium (SGC) (登録日: 2012-06-18, 公開日: 2012-09-05, 最終更新日: 2023-09-13)

• 主引用文献: Zheng, W.,Ibanez, G.,Wu, H.,Blum, G.,Zeng, H.,Dong, A.,Li, F.,Hajian, T.,Allali-Hassani, A.,Amaya, M.F.,Siarheyeva, A.,Yu, W.,Brown, P.J.,Schapira, M.,Vedadi, M.,Min, J.,Luo, M.; Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2.; J.Am.Chem.Soc., 134:18004-18014, 2012; PubMed: 23043551; DOI: 10.1021/ja307060p

実験手法

X-RAY DIFFRACTION (2.1 Å)