4FM5
X-ray structure of des-methylflurbiprofen bound to murine COX-2
Summary for 4FM5
Entry DOI | 10.2210/pdb4fm5/pdb |
Related | 3NT1 3RR3 |
Descriptor | Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, octyl beta-D-glucopyranoside, ... (6 entities in total) |
Functional Keywords | membrane protein, cyclooxygenase, heme binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mus musculus (mouse) |
Total number of polymer chains | 4 |
Total formula weight | 283210.36 |
Authors | Xu, S.,Banerjee, S.,Windsor, M.A.,Marnett, L.J. (deposition date: 2012-06-15, release date: 2012-08-29, Last modification date: 2023-09-13) |
Primary citation | Windsor, M.A.,Hermanson, D.J.,Kingsley, P.J.,Xu, S.,Crews, B.C.,Ho, W.,Keenan, C.M.,Banerjee, S.,Sharkey, K.A.,Marnett, L.J. Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes. ACS Med Chem Lett, 3:759-763, 2012 Cited by PubMed: 22984634DOI: 10.1021/ml3001616 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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