4FM5

X-ray structure of des-methylflurbiprofen bound to murine COX-2

4FM5 の概要

• エントリーDOI: 10.2210/pdb4fm5/pdb
• 関連するPDBエントリー: 3NT1 3RR3
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, octyl beta-D-glucopyranoside, ... (6 entities in total)
• 機能のキーワード: membrane protein, cyclooxygenase, heme binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 283210.36

構造登録者

Xu, S.,Banerjee, S.,Windsor, M.A.,Marnett, L.J. (登録日: 2012-06-15, 公開日: 2012-08-29, 最終更新日: 2023-09-13)

• 主引用文献: Windsor, M.A.,Hermanson, D.J.,Kingsley, P.J.,Xu, S.,Crews, B.C.,Ho, W.,Keenan, C.M.,Banerjee, S.,Sharkey, K.A.,Marnett, L.J.; Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes.; ACS Med Chem Lett, 3:759-763, 2012; PubMed: 22984634; DOI: 10.1021/ml3001616

実験手法

X-RAY DIFFRACTION (2.81 Å)