4FL6

Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215

Summary for 4FL6

• Entry DOI: 10.2210/pdb4fl6/pdb
• Descriptor: Lethal(3)malignant brain tumor-like protein 3, [2-(phenylamino)benzene-1,4-diyl]bis{[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone}, UNKNOWN ATOM OR ION (3 entities in total)
• Functional Keywords: structural genomics consortium, sgc, chromatin modification, transcription repression, mbt repeat, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q96JM7
• Total number of polymer chains: 2
• Total formula weight: 78080.90

Authors

Zhong, N.,Tempel, W.,Ravichandran, M.,Dong, A.,Ingerman, L.A.,Graslund, S.,Frye, S.V.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2012-06-14, release date: 2012-06-27, Last modification date: 2023-09-13)

• Primary citation: James, L.I.,Barsyte-Lovejoy, D.,Zhong, N.,Krichevsky, L.,Korboukh, V.K.,Herold, J.M.,MacNevin, C.J.,Norris, J.L.,Sagum, C.A.,Tempel, W.,Marcon, E.,Guo, H.,Gao, C.,Huang, X.P.,Duan, S.,Emili, A.,Greenblatt, J.F.,Kireev, D.B.,Jin, J.,Janzen, W.P.,Brown, P.J.,Bedford, M.T.,Arrowsmith, C.H.,Frye, S.V.; Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.; Nat. Chem. Biol., 9:184-191, 2013; PubMed: 23292653; DOI: 10.1038/nchembio.1157

Experimental method

X-RAY DIFFRACTION (2.55 Å)