4FL6

Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215

4FL6 の概要

• エントリーDOI: 10.2210/pdb4fl6/pdb
• 分子名称: Lethal(3)malignant brain tumor-like protein 3, [2-(phenylamino)benzene-1,4-diyl]bis{[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone}, UNKNOWN ATOM OR ION (3 entities in total)
• 機能のキーワード: structural genomics consortium, sgc, chromatin modification, transcription repression, mbt repeat, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q96JM7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78080.90

構造登録者

Zhong, N.,Tempel, W.,Ravichandran, M.,Dong, A.,Ingerman, L.A.,Graslund, S.,Frye, S.V.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (登録日: 2012-06-14, 公開日: 2012-06-27, 最終更新日: 2023-09-13)

• 主引用文献: James, L.I.,Barsyte-Lovejoy, D.,Zhong, N.,Krichevsky, L.,Korboukh, V.K.,Herold, J.M.,MacNevin, C.J.,Norris, J.L.,Sagum, C.A.,Tempel, W.,Marcon, E.,Guo, H.,Gao, C.,Huang, X.P.,Duan, S.,Emili, A.,Greenblatt, J.F.,Kireev, D.B.,Jin, J.,Janzen, W.P.,Brown, P.J.,Bedford, M.T.,Arrowsmith, C.H.,Frye, S.V.; Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.; Nat. Chem. Biol., 9:184-191, 2013; PubMed: 23292653; DOI: 10.1038/nchembio.1157

実験手法

X-RAY DIFFRACTION (2.55 Å)