4FJZ
Crystal structure of PI3K-gamma in complex with pyrrolo-pyridine inhibitor 63
Summary for 4FJZ
Entry DOI | 10.2210/pdb4fjz/pdb |
Related | 4FJY 4FLH |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 1'-[7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yl]-6'-(morpholin-4-yl)-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo[3,2-b]pyridine], ... (4 entities in total) |
Functional Keywords | inflammation, cancer, p110, c2 domain, leukocytes, kinase, p85, phosphotransferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P48736 |
Total number of polymer chains | 1 |
Total formula weight | 110719.90 |
Authors | Whittington, D.A.,Tang, J.,Yakowec, P. (deposition date: 2012-06-12, release date: 2012-10-24, Last modification date: 2024-02-28) |
Primary citation | Gonzalez-Lopez de Turiso, F.,Shin, Y.,Brown, M.,Cardozo, M.,Chen, Y.,Fong, D.,Hao, X.,He, X.,Henne, K.,Hu, Y.L.,Johnson, M.G.,Kohn, T.,Lohman, J.,McBride, H.J.,McGee, L.R.,Medina, J.C.,Metz, D.,Miner, K.,Mohn, D.,Pattaropong, V.,Seganish, J.,Simard, J.L.,Wannberg, S.,Whittington, D.A.,Yu, G.,Cushing, T.D. Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors J.Med.Chem., 55:7667-7685, 2012 Cited by PubMed: 22876881DOI: 10.1021/jm300679u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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