4FJZ

Crystal structure of PI3K-gamma in complex with pyrrolo-pyridine inhibitor 63

Summary for 4FJZ

• Entry DOI: 10.2210/pdb4fjz/pdb
• Related: 4FJY 4FLH
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 1'-[7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yl]-6'-(morpholin-4-yl)-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo[3,2-b]pyridine], ... (4 entities in total)
• Functional Keywords: inflammation, cancer, p110, c2 domain, leukocytes, kinase, p85, phosphotransferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P48736
• Total number of polymer chains: 1
• Total formula weight: 110719.90

Authors

Whittington, D.A.,Tang, J.,Yakowec, P. (deposition date: 2012-06-12, release date: 2012-10-24, Last modification date: 2024-02-28)

• Primary citation: Gonzalez-Lopez de Turiso, F.,Shin, Y.,Brown, M.,Cardozo, M.,Chen, Y.,Fong, D.,Hao, X.,He, X.,Henne, K.,Hu, Y.L.,Johnson, M.G.,Kohn, T.,Lohman, J.,McBride, H.J.,McGee, L.R.,Medina, J.C.,Metz, D.,Miner, K.,Mohn, D.,Pattaropong, V.,Seganish, J.,Simard, J.L.,Wannberg, S.,Whittington, D.A.,Yu, G.,Cushing, T.D.; Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors; J.Med.Chem., 55:7667-7685, 2012; PubMed: 22876881; DOI: 10.1021/jm300679u

Experimental method

X-RAY DIFFRACTION (3 Å)