4FJ0

Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and 3,7-dihydroxy flavone

Summary for 4FJ0

Entry DOI	10.2210/pdb4fj0/pdb
Related	3IS3 3ITD 3QWF 3QWH 3QWI 4FIZ 4FJ1 4FJ2
Descriptor	17beta-hydroxysteroid dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	short chain dehydrogenase/reductase, rossmann fold, oxidoreductase, nadp(h), oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Cochliobolus lunatus (Filamentous fungus)
Total number of polymer chains	4
Total formula weight	119724.82
Authors	Cassetta, A.,Lamba, D.,Krastanova, I. (deposition date: 2012-06-11, release date: 2013-07-03, Last modification date: 2023-09-13)
Primary citation	Cassetta, A.,Stojan, J.,Krastanova, I.,Kristan, K.,Brunskole Svegelj, M.,Lamba, D.,Rizner, T.L. Structural basis for inhibition of 17 beta-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17 beta-HSDcl. J. Steroid Biochem. Mol. Biol., 171:80-93, 2017 Cited by PubMed: 28259640 DOI: 10.1016/j.jsbmb.2017.02.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation