4FHK

Crystal Structure of PI3K-gamma in Complex with Imidazopyridazine 19e

4FHK の概要

• エントリーDOI: 10.2210/pdb4fhk/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 3-[2-methyl-6-(pyrazin-2-ylamino)pyrimidin-4-yl]-N-(1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-2-amine, ... (4 entities in total)
• 機能のキーワード: p110, kinase, atp-binding, p84, p101, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P48736
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 110593.69

構造登録者

Shaffer, P.L.,Tang, J.,Yakowec, P. (登録日: 2012-06-06, 公開日: 2013-04-10, 最終更新日: 2023-09-13)

• 主引用文献: Peterson, E.A.,Boezio, A.A.,Andrews, P.S.,Boezio, C.M.,Bush, T.L.,Cheng, A.C.,Choquette, D.,Coats, J.R.,Colletti, A.E.,Copeland, K.W.,DuPont, M.,Graceffa, R.,Grubinska, B.,Kim, J.L.,Lewis, R.T.,Liu, J.,Mullady, E.L.,Potashman, M.H.,Romero, K.,Shaffer, P.L.,Stanton, M.K.,Stellwagen, J.C.,Teffera, Y.,Yi, S.,Cai, T.,La, D.S.; Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.; Bioorg.Med.Chem.Lett., 22:4967-4974, 2012; PubMed: 22765895; DOI: 10.1016/j.bmcl.2012.06.033

実験手法

X-RAY DIFFRACTION (3 Å)