4FHJ
Crystal Structure of PI3K-gamma in Complex with Imidazopyridine 2
Summary for 4FHJ
Entry DOI | 10.2210/pdb4fhj/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-2-amine, ... (4 entities in total) |
Functional Keywords | inhibitor, p110, kinase, transferase, atp-binding, p84, p101, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P48736 |
Total number of polymer chains | 1 |
Total formula weight | 110515.62 |
Authors | Shaffer, P.L.,Tang, J.,Yakowec, P. (deposition date: 2012-06-06, release date: 2012-07-18, Last modification date: 2023-09-13) |
Primary citation | Peterson, E.A.,Boezio, A.A.,Andrews, P.S.,Boezio, C.M.,Bush, T.L.,Cheng, A.C.,Choquette, D.,Coats, J.R.,Colletti, A.E.,Copeland, K.W.,Dupont, M.,Graceffa, R.,Grubinska, B.,Kim, J.L.,Lewis, R.T.,Liu, J.,Mullady, E.L.,Potashman, M.H.,Romero, K.,Shaffer, P.L.,Stanton, M.K.,Stellwagen, J.C.,Teffera, Y.,Yi, S.,Cai, T.,La, D.S. Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors. Bioorg.Med.Chem.Lett., 22:4967-4974, 2012 Cited by PubMed: 22765895DOI: 10.1016/j.bmcl.2012.06.033 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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