4FHH
Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition
Summary for 4FHH
Entry DOI | 10.2210/pdb4fhh/pdb |
Related | 4FHI |
Descriptor | Vitamin D3 receptor A, Nuclear receptor coactivator 2, N-hydroxy-2-{4-[3-(4-{[(2S)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetamide, ... (4 entities in total) |
Functional Keywords | ligand binding domain, apha helical sandwich, alpha helical sandwich, transcription factor, adn coregulators, phosphorylation and hdac inhibitor, nucleus, transcription-protein binding-inhibitor complex, transcription/protein binding/inhibitor |
Biological source | Danio rerio (leopard danio,zebra danio,zebra fish) More |
Cellular location | Nucleus: Q9PTN2 Q15596 |
Total number of polymer chains | 2 |
Total formula weight | 35954.01 |
Authors | Fischer, J.,Wang, T.T.,Kaldre, D.,Rochel, N.,Moras, D.,White, J.H.,Gleason, J.L. (deposition date: 2012-06-06, release date: 2012-09-19, Last modification date: 2024-02-28) |
Primary citation | Fischer, J.,Wang, T.T.,Kaldre, D.,Rochel, N.,Moras, D.,White, J.H.,Gleason, J.L. Synthetically accessible non-secosteroidal hybrid molecules combining vitamin d receptor agonism and histone deacetylase inhibition. Chem.Biol., 19:963-971, 2012 Cited by PubMed: 22921063DOI: 10.1016/j.chembiol.2012.05.024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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