4FHH

Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition

4FHH の概要

• エントリーDOI: 10.2210/pdb4fhh/pdb
• 関連するPDBエントリー: 4FHI
• 分子名称: Vitamin D3 receptor A, Nuclear receptor coactivator 2, N-hydroxy-2-{4-[3-(4-{[(2S)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetamide, ... (4 entities in total)
• 機能のキーワード: ligand binding domain, apha helical sandwich, alpha helical sandwich, transcription factor, adn coregulators, phosphorylation and hdac inhibitor, nucleus, transcription-protein binding-inhibitor complex, transcription/protein binding/inhibitor
• 由来する生物種: Danio rerio (leopard danio,zebra danio,zebra fish); 詳細
• 細胞内の位置: Nucleus: Q9PTN2 Q15596
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35954.01

構造登録者

Fischer, J.,Wang, T.T.,Kaldre, D.,Rochel, N.,Moras, D.,White, J.H.,Gleason, J.L. (登録日: 2012-06-06, 公開日: 2012-09-19, 最終更新日: 2024-02-28)

• 主引用文献: Fischer, J.,Wang, T.T.,Kaldre, D.,Rochel, N.,Moras, D.,White, J.H.,Gleason, J.L.; Synthetically accessible non-secosteroidal hybrid molecules combining vitamin d receptor agonism and histone deacetylase inhibition.; Chem.Biol., 19:963-971, 2012; PubMed: 22921063; DOI: 10.1016/j.chembiol.2012.05.024

実験手法

X-RAY DIFFRACTION (2.33 Å)