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4FGY

Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity

Summary for 4FGY
Entry DOI10.2210/pdb4fgy/pdb
DescriptorPeroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, (4R,6S,8S,12R,14R,16Z,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9,11-dioxodocos-16-enoic acid, ... (4 entities in total)
Functional Keywordsppar lbd, nuclear receptor fold, ligand binding, gene transcription, transcription-transferase-antibiotic complex, transcription/transferase/antibiotic
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: P37231 Q15788
Total number of polymer chains2
Total formula weight32990.60
Authors
Wang, R.,Li, Y. (deposition date: 2012-06-05, release date: 2013-03-20, Last modification date: 2024-02-28)
Primary citationZheng, W.,Feng, X.,Qiu, L.,Pan, Z.,Wang, R.,Lin, S.,Hou, D.,Jin, L.,Li, Y.
Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes.
Diabetologia, 56:401-411, 2013
Cited by
PubMed: 23178929
DOI: 10.1007/s00125-012-2777-9
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.84 Å)
Structure validation

217705

数据于2024-03-27公开中

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