4FGY

Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity

4FGY の概要

• エントリーDOI: 10.2210/pdb4fgy/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, (4R,6S,8S,12R,14R,16Z,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9,11-dioxodocos-16-enoic acid, ... (4 entities in total)
• 機能のキーワード: ppar lbd, nuclear receptor fold, ligand binding, gene transcription, transcription-transferase-antibiotic complex, transcription/transferase/antibiotic
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P37231 Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32990.60

構造登録者

Wang, R.,Li, Y. (登録日: 2012-06-05, 公開日: 2013-03-20, 最終更新日: 2024-02-28)

• 主引用文献: Zheng, W.,Feng, X.,Qiu, L.,Pan, Z.,Wang, R.,Lin, S.,Hou, D.,Jin, L.,Li, Y.; Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes.; Diabetologia, 56:401-411, 2013; PubMed: 23178929; DOI: 10.1007/s00125-012-2777-9

実験手法

X-RAY DIFFRACTION (2.84 Å)