4FGJ

Oxidized quinone reductase 2 in complex with primaquine

Summary for 4FGJ

• Entry DOI: 10.2210/pdb4fgj/pdb
• Related: 4FGK 4FGL
• Descriptor: Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
• Functional Keywords: primaquine, fmn reductase superfamily, metallo-flavoprotein, rossmann fold, two-electron reduction of quinones to hydroquinones, fad binding, zn binding, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P16083
• Total number of polymer chains: 2
• Total formula weight: 54622.13

Authors

Leung, K.K.,Shilton, B.H. (deposition date: 2012-06-04, release date: 2013-03-13, Last modification date: 2024-02-28)

• Primary citation: Leung, K.K.,Shilton, B.H.; Crystal structures of quinone reductase 2 bound to antimalarial drugs reveal conformational change upon reduction; J.Biol.Chem., 2013

Experimental method

X-RAY DIFFRACTION (1.346 Å)