4FGG

S. aureus dihydrofolate reductase co-crystallized with propyl-DAP isobutenyl-dihydrophthalazine inhibitor

4FGG の概要

• エントリーDOI: 10.2210/pdb4fgg/pdb
• 関連するPDBエントリー: 3M08 4FGH
• 分子名称: Dihydrofolate reductase, (2E)-3-{5-[(2,4-diamino-6-propylpyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(2-methylprop-1-en-1-yl)phthalazin-2(1H)-yl]prop-2-en-1-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: dihydrofolate reductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20118.69

構造登録者

Bourne, C.R.,Barrow, W.W. (登録日: 2012-06-04, 公開日: 2013-01-09, 最終更新日: 2024-02-28)

• 主引用文献: Nammalwar, B.,Bourne, C.R.,Bunce, R.A.,Wakeham, N.,Bourne, P.C.,Ramnarayan, K.,Mylvaganam, S.,Berlin, K.D.,Barrow, E.W.,Barrow, W.W.; Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines.; Chemmedchem, 7:1974-1982, 2012; PubMed: 22930550; DOI: 10.1002/cmdc.201200291

実験手法

X-RAY DIFFRACTION (2.3 Å)