4FFV

Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab

Summary for 4FFV

• Entry DOI: 10.2210/pdb4ffv/pdb
• Descriptor: Dipeptidyl peptidase 4, 11A19 Fab light chain, 11A19 Fab heavy chain, ... (4 entities in total)
• Functional Keywords: hydrolase, hydrolase-immune system, inhibitor complex, hydrolase/immune system, inhibitor
• Biological source: Rattus norvegicus (brown rat,rat,rats); More
• Cellular location: Dipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein: P14740
• Total number of polymer chains: 6
• Total formula weight: 261019.77

Authors

Wang, Z.,Sudom, A.,Walker, N.P.,Min, X. (deposition date: 2012-06-01, release date: 2012-12-12, Last modification date: 2021-05-19)

• Primary citation: Tang, J.,Majeti, J.,Sudom, A.,Xiong, Y.,Lu, M.,Liu, Q.,Higbee, J.,Zhang, Y.,Wang, Y.,Wang, W.,Cao, P.,Xia, Z.,Johnstone, S.,Yang, X.,Yu, T.,Sharkov, N.,Walker, N.,Tu, H.,Shen, W.,Wang, Z.,Min, X.; An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition; To be published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)