4FFV

Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab

4FFV の概要

• エントリーDOI: 10.2210/pdb4ffv/pdb
• 分子名称: Dipeptidyl peptidase 4, 11A19 Fab light chain, 11A19 Fab heavy chain, ... (4 entities in total)
• 機能のキーワード: hydrolase, hydrolase-immune system, inhibitor complex, hydrolase/immune system, inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats); 詳細
• 細胞内の位置: Dipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein: P14740
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 261019.77

構造登録者

Wang, Z.,Sudom, A.,Walker, N.P.,Min, X. (登録日: 2012-06-01, 公開日: 2012-12-12, 最終更新日: 2021-05-19)

• 主引用文献: Tang, J.,Majeti, J.,Sudom, A.,Xiong, Y.,Lu, M.,Liu, Q.,Higbee, J.,Zhang, Y.,Wang, Y.,Wang, W.,Cao, P.,Xia, Z.,Johnstone, S.,Yang, X.,Yu, T.,Sharkov, N.,Walker, N.,Tu, H.,Shen, W.,Wang, Z.,Min, X.; An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition; To be published,

実験手法

X-RAY DIFFRACTION (2.4 Å)