4FCF

K234R: apo structure of inhibitor resistant beta-lactamase

4FCF の概要

• エントリーDOI: 10.2210/pdb4fcf/pdb
• 分子名称: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, 2-AMINOETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: class a beta-lactamse, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30077.38

構造登録者

Rodkey, E.A.,van den Akker, F. (登録日: 2012-05-24, 公開日: 2012-12-26, 最終更新日: 2013-10-02)

• 主引用文献: Winkler, M.L.,Rodkey, E.A.,Taracila, M.A.,Drawz, S.M.,Bethel, C.R.,Papp-Wallace, K.M.,Smith, K.M.,Xu, Y.,Dwulit-Smith, J.R.,Romagnoli, C.,Caselli, E.,Prati, F.,van den Akker, F.,Bonomo, R.A.; Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) beta-lactamase.; J.Med.Chem., 56:1084-1097, 2013; PubMed: 23252553; DOI: 10.1021/jm301490d

実験手法

X-RAY DIFFRACTION (1.09 Å)