4FCD

Potent and Selective Phosphodiesterase 10A Inhibitors

Summary for 4FCD

• Entry DOI: 10.2210/pdb4fcd/pdb
• Related: 4FCB
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: binding sites, cyclic amp, cyclic gmp, humans, hydrolysis, ligands, phosphodiesterase inhibitors, phosphoric diester hydrolases, recombinant proteins, structure-activity relationship, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9Y233
• Total number of polymer chains: 2
• Total formula weight: 80101.87

Authors

Parris, K.D. (deposition date: 2012-05-24, release date: 2012-09-05, Last modification date: 2024-02-28)

• Primary citation: Malamas, M.S.,Stange, H.,Schindler, R.,Lankau, H.J.,Grunwald, C.,Langen, B.,Egerland, U.,Hage, T.,Ni, Y.,Erdei, J.,Fan, K.Y.,Parris, K.,Marquis, K.L.,Grauer, S.,Brennan, J.,Navarra, R.,Graf, R.,Harrison, B.L.,Robichaud, A.,Kronbach, T.,Pangalos, M.N.,Brandon, N.J.,Hoefgen, N.; Novel triazines as potent and selective phosphodiesterase 10A inhibitors.; Bioorg.Med.Chem.Lett., 22:5876-5884, 2012; PubMed: 22902656; DOI: 10.1016/j.bmcl.2012.07.076

Experimental method

X-RAY DIFFRACTION (2.02 Å)