4FAJ

Structure and mode of peptide binding of pheromone receptor PrgZ

4FAJ の概要

• エントリーDOI: 10.2210/pdb4faj/pdb
• 分子名称: PrgZ, Sex pheromone cCF10, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: substrate binding protein, peptide binding protein, pheromone, extracellular, membrane anchored
• 由来する生物種: Enterococcus faecalis; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64563.60

構造登録者

Berntsson, R.P.-A.,Schuurman-Wolters, G.K.,Dunny, K.,Slotboom, D.J.,Poolman, B. (登録日: 2012-05-22, 公開日: 2012-09-12, 最終更新日: 2024-02-28)

主引用文献

Berntsson, R.P.,Schuurman-Wolters, G.K.,Dunny, G.,Slotboom, D.J.,Poolman, B.
Structure and Mode of Peptide Binding of Pheromone Receptor PrgZ.
J.Biol.Chem., 287:37165-37170, 2012

PubMed Abstract: We present the crystal structure of the pheromone receptor protein PrgZ from Enterococcus faecalis in complex with the heptapeptide cCF10 (LVTLVFV), which is used in signaling between conjugative recipient and donor cells. Comparison of PrgZ with homologous oligopeptide-binding proteins (AppA and OppA) explains the high specificity of PrgZ for hydrophobic heptapeptides versus the promiscuity of peptide binding in the homologous proteins.

PubMed: 22948145
DOI: 10.1074/jbc.M112.386334

実験手法

X-RAY DIFFRACTION (1.9 Å)