4F9W

Human P38alpha MAPK in Complex with a Novel and Selective Small Molecule Inhibitor

4F9W の概要

• エントリーDOI: 10.2210/pdb4f9w/pdb
• 関連するPDBエントリー: 4EWQ 4F9Y 4FA2
• 分子名称: Mitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, N,N-dimethyl-6-(naphthalen-2-yl)-5-(pyridin-4-yl)pyridazin-3-amine, ... (8 entities in total)
• 機能のキーワード: protein kinase catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45055.48

構造登録者

Grum-Tokars, V.L.,Minasov, G.,Anderson, W.F.,Watterson, D.M. (登録日: 2012-05-21, 公開日: 2013-06-05, 最終更新日: 2023-09-13)

• 主引用文献: Watterson, D.M.,Grum-Tokars, V.L.,Roy, S.M.,Schavocky, J.P.,Bradaric, B.D.,Bachstetter, A.D.,Xing, B.,Dimayuga, E.,Saeed, F.,Zhang, H.,Staniszewski, A.,Pelletier, J.C.,Minasov, G.,Anderson, W.F.,Arancio, O.,Van Eldik, L.J.; Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.; Plos One, 8:e66226-e66226, 2013; PubMed: 23840427; DOI: 10.1371/journal.pone.0066226

実験手法

X-RAY DIFFRACTION (2 Å)