4F8U

Crystal structure of the bacterial ribosomal decoding site in complex with sisomicin (C2 form)

Summary for 4F8U

• Entry DOI: 10.2210/pdb4f8u/pdb
• Related: 4F8V
• Descriptor: RNA (5'-R(P*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'), RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'), (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, ... (4 entities in total)
• Functional Keywords: decoding, ribosome, rna-antibiotic complex, rna/antibiotic
• Total number of polymer chains: 2
• Total formula weight: 14687.37

Authors

Kondo, J.,Koganei, M.,Kasahara, T. (deposition date: 2012-05-18, release date: 2012-08-15, Last modification date: 2024-03-20)

• Primary citation: Kondo, J.,Koganei, M.,Kasahara, T.; Crystal structure and specific binding mode of sisomicin to the bacterial ribosomal decoding site.; Acs Med.Chem.Lett., 3:741-744, 2012; PubMed: 24900542; DOI: 10.1021/ml300145y

Experimental method

X-RAY DIFFRACTION (2 Å)