4F56

The bicyclic intermediate structure provides insights into the desuccinylation mechanism of SIRT5

Summary for 4F56

• Entry DOI: 10.2210/pdb4f56/pdb
• Related: 3RIG 3RIY 4f4u
• Descriptor: NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial, peptide from Histone H3.1, ZINC ION, ... (5 entities in total)
• Functional Keywords: zn-binding domain, rossmann fold domain, nad-dependent demalonylase and desuccinylase, mitochondrial sirtuin, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion matrix. Isoform 1: Cytoplasm . Isoform 2: Mitochondrion : Q9NXA8; Nucleus: P68431
• Total number of polymer chains: 4
• Total formula weight: 63304.16

Authors

Zhou, Y.,Hao, Q. (deposition date: 2012-05-11, release date: 2012-06-20, Last modification date: 2023-11-08)

• Primary citation: Zhou, Y.,Zhang, H.,He, B.,Du, J.,Lin, H.,Cerione, R.A.,Hao, Q.; The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5); J.Biol.Chem., 287:28307-28314, 2012; PubMed: 22767592; DOI: 10.1074/jbc.M112.384511

Experimental method

X-RAY DIFFRACTION (1.7 Å)