4F56

The bicyclic intermediate structure provides insights into the desuccinylation mechanism of SIRT5

4F56 の概要

• エントリーDOI: 10.2210/pdb4f56/pdb
• 関連するPDBエントリー: 3RIG 3RIY 4f4u
• 分子名称: NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial, peptide from Histone H3.1, ZINC ION, ... (5 entities in total)
• 機能のキーワード: zn-binding domain, rossmann fold domain, nad-dependent demalonylase and desuccinylase, mitochondrial sirtuin, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Mitochondrion matrix. Isoform 1: Cytoplasm . Isoform 2: Mitochondrion : Q9NXA8; Nucleus: P68431
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 63304.16

構造登録者

Zhou, Y.,Hao, Q. (登録日: 2012-05-11, 公開日: 2012-06-20, 最終更新日: 2023-11-08)

• 主引用文献: Zhou, Y.,Zhang, H.,He, B.,Du, J.,Lin, H.,Cerione, R.A.,Hao, Q.; The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5); J.Biol.Chem., 287:28307-28314, 2012; PubMed: 22767592; DOI: 10.1074/jbc.M112.384511

実験手法

X-RAY DIFFRACTION (1.7 Å)