4F4Q
Crystal structure of M. smegmatis DprE1 in complex with FAD and covalently bound BTZ043
Summary for 4F4Q
Entry DOI | 10.2210/pdb4f4q/pdb |
Descriptor | DprE1, 8-(hydroxyamino)-2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total) |
Functional Keywords | fad domain, oxidase, btz043 covalently bound to cys394, oxidoreductase |
Biological source | Mycobacterium smegmatis |
Cellular location | Periplasm : A0R607 |
Total number of polymer chains | 1 |
Total formula weight | 52485.93 |
Authors | Neres, J.,Pojer, F.,Molteni, E.,Chiarelli, L.,Riccardi, G.,Mattevi, A.,Cole, S.T.,Binda, C. (deposition date: 2012-05-11, release date: 2012-09-05, Last modification date: 2023-09-13) |
Primary citation | Neres, J.,Pojer, F.,Molteni, E.,Chiarelli, L.R.,Dhar, N.,Boy-Rottger, S.,Buroni, S.,Fullam, E.,Degiacomi, G.,Lucarelli, A.P.,Read, R.J.,Zanoni, G.,Edmondson, D.E.,De Rossi, E.,Pasca, M.R.,McKinney, J.D.,Dyson, P.J.,Riccardi, G.,Mattevi, A.,Cole, S.T.,Binda, C. Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis. Sci Transl Med, 4:150ra121-150ra121, 2012 Cited by PubMed: 22956199DOI: 10.1126/scitranslmed.3004395 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.619 Å) |
Structure validation
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