4F3K

Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with homocysteine-DADMe-Immucillin-A

Summary for 4F3K

• Entry DOI: 10.2210/pdb4f3k/pdb
• Related: 4F1W 4F2P 4F2W 4F3C
• Descriptor: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, {(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-hydroxypyrrolidin-3-yl}-L-methionine, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: l-methionine biosynthetic process from s-adenosylmethionine, l-methionine salvage from methylthioadenosine, 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase, adenosylhomocysteine nucleosidase activity, methylthioadenosine nucleosidase activity, hydrolase activity, acting on glycosyl bonds, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Salmonella enterica subsp. enterica serovar Choleraesuis
• Total number of polymer chains: 2
• Total formula weight: 53533.21

Authors

Haapalainen, A.M.,Thomas, K.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2012-05-09, release date: 2013-05-01, Last modification date: 2024-02-28)

• Primary citation: Haapalainen, A.M.,Thomas, K.,Tyler, P.C.,Evans, G.B.,Almo, S.C.,Schramm, V.L.; Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with homocysteine-DADMe-Immucillin-A; Structure, 21:963-974, 2013; PubMed: 23685211; DOI: 10.1016/j.str.2013.04.009

Experimental method

X-RAY DIFFRACTION (1.85 Å)