4F2P

Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with diEtglycol-thio-DADMe-Immucillin-A

4F2P の概要

• エントリーDOI: 10.2210/pdb4f2p/pdb
• 関連するPDBエントリー: 4F1W 4F2W
• 分子名称: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[2-(2-hydroxyethoxy)ethyl]sulfanyl}methyl)pyrrolidin-3- ol, ACETATE ION, ... (6 entities in total)
• 機能のキーワード: l-methionine biosynthetic process from s-adenosylmethionine, l-methionine salvage from methylthioadenosine, 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase, adenosylhomocysteine nucleosidase activity, methylthioadenosine nucleosidase activity, acting on glycosyl bonds, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Salmonella enterica subsp. enterica serovar Choleraesuis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53780.47

構造登録者

Haapalainen, A.M.,Thomas, K.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (登録日: 2012-05-08, 公開日: 2013-05-01, 最終更新日: 2024-02-28)

• 主引用文献: Haapalainen, A.M.,Thomas, K.,Tyler, P.C.,Evans, G.B.,Almo, S.C.,Schramm, V.L.; Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with diEtglycol-thio-DADMe-Immucillin-A; Structure, 21:963-974, 2013; PubMed: 23685211; DOI: 10.1016/j.str.2013.04.009

実験手法

X-RAY DIFFRACTION (1.64 Å)