4F0Y

Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-IG from Acinetobacter haemolyticus, apo

4F0Y の概要

• エントリーDOI: 10.2210/pdb4f0y/pdb
• 関連するPDBエントリー: 4EVY
• 分子名称: Aminoglycoside N(6')-acetyltransferase type 1, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: center for structural genomics of infectious diseases (csgid), niaid, national institute of allergy and infectious diseases, gnat superfamily, gcn5-related n-acetyltransferase superfamily, n-acetyltransferase fold, antibiotic resistance, aminoglycosides, acetyl coenzyme a, intracellular, transferase
• 由来する生物種: Acinetobacter haemolyticus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38137.74

構造登録者

Stogios, P.J.,Evdokimova, E.,Dong, A.,Minasov, G.,Yim, V.,Courvalin, P.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2012-05-05, 公開日: 2012-05-16, 最終更新日: 2023-09-13)

• 主引用文献: Stogios, P.J.,Kuhn, M.L.,Evdokimova, E.,Law, M.,Courvalin, P.,Savchenko, A.; Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.; ACS Infect Dis., 3:132-143, 2017; PubMed: 27785912; DOI: 10.1021/acsinfecdis.6b00058

実験手法

X-RAY DIFFRACTION (2.56 Å)