4F0V

Crystal structure of type effector Tse1 from Pseudomonas aeruginousa

4F0V の概要

• エントリーDOI: 10.2210/pdb4f0v/pdb
• 関連するPDBエントリー: 4E0W
• 分子名称: Putative uncharacterized protein, SUCCINIC ACID (3 entities in total)
• 機能のキーワード: nlpc/p60 domain, type vi amidase effector, hydrolase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20314.83

構造登録者

Zhang, H.,Gao, Z.Q.,Dong, Y.H. (登録日: 2012-05-05, 公開日: 2012-06-27, 最終更新日: 2024-11-13)

主引用文献

Zhang, H.,Gao, Z.Q.,Su, X.D.,Dong, Y.H.
Crystal structure of type VI effector Tse1 from Pseudomonas aeruginosa.
Febs Lett., 586:3193-3199, 2012

PubMed Abstract: The type VI secretion systems (T6SS) have emerging roles in interspecies competition. In order to have an advantage in defense against other organisms, this system in Pseudomonas aeruginosa delivers a peptidoglycan amidase (Tse1) to the periplasmic space of a competitor. An immune protein (Tsi1) is also produced by the bacterium to protect itself from damage caused by Tse1. Tsi1 directly interacts with Tse1. We report that the crystal structure of Tse1 displays a common CHAP protein fold. Strikingly, our structures showed that the third residue in the catalytic triad may be novel as this residue type has not been observed previously.

PubMed: 22750141
DOI: 10.1016/j.febslet.2012.06.036

実験手法

X-RAY DIFFRACTION (1.6 Å)