4EZA

Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2

Summary for 4EZA

• Entry DOI: 10.2210/pdb4eza/pdb
• Descriptor: Ras GTPase-activating-like protein IQGAP2 (2 entities in total)
• Functional Keywords: gap, structural genomics consortium, sgc, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 26464.69

Authors

Van Aalten, D.M.F.,Dixon, M.J.,Gray, A.,Schenning, M.,Agacan, M.,Leslie, N.R.,Downes, C.P.,Batty, I.H.,Nedyalkova, L.,Tempel, W.,Tong, Y.,Zhong, N.,Crombet, L.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2012-05-02, release date: 2012-05-16, Last modification date: 2024-02-28)

• Primary citation: Dixon, M.J.,Gray, A.,Schenning, M.,Agacan, M.,Tempel, W.,Tong, Y.,Nedyalkova, L.,Park, H.W.,Leslie, N.R.,van Aalten, D.M.,Downes, C.P.,Batty, I.H.; IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold.; J.Biol.Chem., 287:22483-22496, 2012; PubMed: 22493426; DOI: 10.1074/jbc.M112.352773

Experimental method

X-RAY DIFFRACTION (1.5 Å)