4EY7

Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Donepezil

4EY7 の概要

• エントリーDOI: 10.2210/pdb4ey7/pdb
• 分子名称: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE, ... (7 entities in total)
• 機能のキーワード: acetylcholinesterase, hydrolase, donepezil, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121325.70

構造登録者

Cheung, J.,Rudolph, M.,Burshteyn, F.,Cassidy, M.,Gary, E.,Love, J.,Height, J.,Franklin, M. (登録日: 2012-05-01, 公開日: 2012-10-17, 最終更新日: 2023-09-13)

• 主引用文献: Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.S.,Gary, E.N.,Love, J.,Franklin, M.C.,Height, J.J.; Structures of human acetylcholinesterase in complex with pharmacologically important ligands.; J.Med.Chem., 55:10282-10286, 2012; PubMed: 23035744; DOI: 10.1021/jm300871x

実験手法

X-RAY DIFFRACTION (2.3509 Å)