4EWR
X-ray structure of WDR5-SETd1a Win motif peptide binary complex
Summary for 4EWR
Entry DOI | 10.2210/pdb4ewr/pdb |
Related | 4ERQ 4ERY 4ERZ 4ES0 4ESG |
Descriptor | WD repeat-containing protein 5, Histone-lysine N-methyltransferase SETD1A (3 entities in total) |
Functional Keywords | wd40, win motif, beta propeller, 3-10 helix, lysine methyltransferase, setd1a, rbbp5, mll1, ash2l, core complex, histone, transcription-transferase complex, transcription/transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P61964 Nucleus speckle : O15047 |
Total number of polymer chains | 2 |
Total formula weight | 35887.53 |
Authors | Dharmarajan, V.,Lee, J.-H.,Patel, A.,Skalnik, D.G.,Cosgrove, M.S. (deposition date: 2012-04-27, release date: 2012-05-30, Last modification date: 2024-02-28) |
Primary citation | Dharmarajan, V.,Lee, J.H.,Patel, A.,Skalnik, D.G.,Cosgrove, M.S. Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. J.Biol.Chem., 287:27275-27289, 2012 Cited by PubMed: 22665483DOI: 10.1074/jbc.M112.364125 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.503 Å) |
Structure validation
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