4EWQ
Human p38 alpha MAPK in complex with a pyridazine based inhibitor
4EWQ の概要
エントリーDOI | 10.2210/pdb4ewq/pdb |
分子名称 | Mitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 3-phenyl-4-(pyridin-4-yl)-6-[4-(pyrimidin-2-yl)piperazin-1-yl]pyridazine, ... (10 entities in total) |
機能のキーワード | serine/threonine-protein kinase, structural genomics, center for structural genomics of infectious diseases, csgid, protein kinase domain, transferase, atp binding, phosphorylation, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 45502.31 |
構造登録者 | Grum-Tokars, V.,Minasov, G.,Roy, S.,Schavocky, J.,Winsor, J.,Watterson, D.M.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2012-04-27, 公開日: 2012-06-27, 最終更新日: 2023-09-13) |
主引用文献 | Roy, S.M.,Minasov, G.,Arancio, O.,Chico, L.W.,Van Eldik, L.J.,Anderson, W.F.,Pelletier, J.C.,Watterson, D.M. A Selective and Brain Penetrant p38 alpha MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction. J.Med.Chem., 62:5298-5311, 2019 Cited by PubMed: 30978288DOI: 10.1021/acs.jmedchem.9b00058 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.1 Å) |
構造検証レポート
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