4EWL

Crystal Structure of MshB with glycerol and Acetate bound in the active site

Summary for 4EWL

• Entry DOI: 10.2210/pdb4ewl/pdb
• Descriptor: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, GLYCEROL, ... (6 entities in total)
• Functional Keywords: active site, glycerol, acetate, tyrosine 142, histidine 144, mshb, hydrolase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 64708.46

Authors

Broadley, S.G.,Sewell, B.T.,Weber, B.W.,Marakalala, M.J.,Steenkamp, D.J. (deposition date: 2012-04-27, release date: 2012-09-26, Last modification date: 2023-09-13)

• Primary citation: Broadley, S.G.,Gumbart, J.C.,Weber, B.W.,Marakalala, M.J.,Steenkamp, D.J.,Sewell, B.T.; A new crystal form of MshB from Mycobacterium tuberculosis with glycerol and acetate in the active site suggests the catalytic mechanism.; Acta Crystallogr.,Sect.D, 68:1450-1459, 2012; PubMed: 23090394; DOI: 10.1107/S090744491203449X

Experimental method

X-RAY DIFFRACTION (1.85 Å)