4ESR

Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors

Summary for 4ESR

Entry DOI	10.2210/pdb4esr/pdb
Descriptor	Jouberin, DI(HYDROXYETHYL)ETHER (3 entities in total)
Functional Keywords	ahi-1, ahi1, ahi-1 sh3 domain, sh3 domain, dynamin-2, protein binding, chronic myeloid leukemia
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, cilium basal body : Q8N157
Total number of polymer chains	2
Total formula weight	16227.67
Authors	Van Petegem, X.F.,Liu, P.X.,Lobo, P.,Jiang, X. (deposition date: 2012-04-23, release date: 2012-06-06, Last modification date: 2024-02-28)
Primary citation	Liu, X.,Chen, M.,Lobo, P.,An, J.,Grace Cheng, S.W.,Moradian, A.,Morin, G.B.,Van Petegem, F.,Jiang, X. Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors. Proteomics, 12:2094-2106, 2012 Cited by PubMed: 22623184 DOI: 10.1002/pmic.201100553 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation